PARP inhibitors are a class of drugs that are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP), which plays a role in repairing DNA in damaged cells.

Jan 16, 2025 · PARP inhibitors are a targeted therapy treatment for some forms of cancers that involve changes (mutations) in the BRCA gene. This includes some types of breast, ovarian and prostate …

Apr 3, 2024 · PARP inhibitors are a type of targeted therapy commonly used to treat breast cancer and ovarian cancer, among others. They target PARP, or poly (ADP-ribose) polymerase, which is a …

Clinically, PARP inhibitors (PARPi), such as olaparib, niraparib, rucaparib, and talazoparib, exploit synthetic lethality in homologous recombination–deficient tumors and are increasingly applied in …

Apr 14, 2023 · Poly (ADP-ribose) polymerase inhibitors, also called PARP inhibitors, are targeted therapies that are used to treat cancer. PARP is a protein that has a role in cellular growth, …

Jul 26, 2025 · PARP enzymes, particularly PARP1 and PARP2, are central to the body’s DNA repair machinery. Their main job is to detect and respond to DNA damage, specifically single-strand …

Cancer cells that already have alterations in BRCA1, BRCA2, or other DDR genes will instead rely on the repair protein called PARP. Blocking PARP with a medication makes the cancer cells unable to …

PARP inhibitors are a type of targeted cancer drug, they include olaparib, niraparib and talazoparib. They are a treatment for several types of cancer including ovarian, breast and prostate cancer.

PARP (poly ADP-ribose polymerase) are proteins that bind to broken strands of DNA and recruit other proteins to repair damaged DNA. There are multiple pathways (controlled by multiple genes) …

A substance that blocks an enzyme in cells called PARP. PARP helps repair DNA when it becomes damaged. DNA damage may be caused by many things, including exposure to UV light, radiation, …