Causes of an elevated alkaline phosphatase - UpToDate
Alkaline phosphatase may be derived from several sites including the liver, bone, third trimester placenta, intestine, and kidneys. An elevation in alkaline phosphatase with a normal gamma-glutamyl …
Approach to the patient with abnormal liver tests - UpToDate
Apr 8, 2025 · Liver enzymes that are commonly measured in the serum include: Serum aminotransferases: alanine aminotransferase (ALT; formerly called SGPT) and aspartate …
Transient hyperphosphatasemia of infancy and early childhood
Dec 7, 2023 · Evaluation of an older child or adult with elevated alkaline phosphatase, or of any individual with elevations of multiple liver enzymes, is discussed separately.
Approach to evaluating pregnant patients with elevated liver ...
Feb 12, 2025 · Approach to evaluating elevated liver tests in pregnant patients without acute liver failure
Approach to the patient with abnormal liver biochemical and
Apr 5, 2022 · Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin are biochemical markers of liver injury. Albumin, bilirubin, and prothrombin time are …
Enzymatic measures of hepatic cholestasis (alkaline phosphatase, 5 ...
Apr 8, 2024 · Genetic mutations of the intestinal alkaline phosphatase gene are thought to contribute to some forms of chronic inflammatory diseases [8]. In bone, the enzyme is involved with calcification. …
Approach to evaluating pregnant patients with elevated liver ...
Apr 30, 2021 · For pregnant patients, assessing clinical features and interpreting the liver biochemistries must also take into account the timing of symptom onset and gestational age because these factors …
Clinical manifestations and diagnosis of Paget disease of bone
Jan 27, 2025 · The diagnosis in such patients is usually made incidentally following a routine chemistry screen showing an elevated serum concentration of alkaline phosphatase of bone origin or an …
Wilson disease: Clinical manifestations, diagnosis, and ... - UpToDate
Jun 5, 2025 · The differential diagnosis includes essential tremor, young-onset Parkinson disease, and generalized dystonia. The presence of KF rings, seen in nearly all patients with neurologic Wilson …
Hypophosphatasia: Clinical manifestations and diagnosis
Jul 21, 2025 · In HPP, deficient TNSALP activity leads to low levels of serum alkaline phosphatase (ALP) activity with accumulation of natural substrates like inorganic pyrophosphate (PPi) [3] and …