G protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors, orchestrating a vast array of physiological responses by transducing extracellular signals into ...
This new technique for studying cell receptors could have sweeping implications for drug development
Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...
DEATH DUEL: One TNF receptor 1 pathway activates apoptosis, another triggers gene expression-roles in seeming opposition, says David Goeddel. H. Hsu, H Shu, M. Pan, D.V. Goeddel, "TRADD-TRAF2 and ...
One in every three FDA-approved drugs targets a single superfamily of receptors dotting the surfaces of human cells. From beta blockers to antihistamines, these essential, life-saving medications ...
Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. An international team of ...
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