Run by Roger Perlmutter and backed by more than $1 billion in private funding, Eikon will use the IPO proceeds to advance a ...

PARP inhibitors are a type of cancer drug. PARP stands for poly adenosine diphosphate-ribose polymerase, a type of enzyme that helps repair DNA damage in cells. PARP inhibitors work by preventing ...

An educational session helps oncologists understand the decision-making process for selecting treatments for recurrent ovarian cancer. New therapeutic options—with more on the horizon—offer ...

Please provide your email address to receive an email when new articles are posted on . Poly(ADP-ribose) polymerase, or PARP, inhibitors appeared associated with increased risk for secondary ...

Inhibition of poly(ADP-ribose) polymerase (PARP) ameliorates alcoholic steatohepatitis and NASH in animal models, highlighting the therapeutic potential for PARP inhibitors as a treatment for ...

CHICAGO -- Men with homologous recombination repair (HRR)-deficient, metastatic, castration-sensitive prostate cancer (mCSPC) lived significantly longer without disease progression when they received ...

AstraZeneca’s Lynparza and Tesaro’s Zejula—part of an emerging class of cancer medicines known as PARP inhibitors—are on the market and being used to treat ovarian cancer with BRCA mutations. Now new ...

Niraparib approved for all-comers whose tumors responded to chemotherapy Platinum response serves as a clinical biomarker indicating potential DNA repair deficiency. The FDA restricted ...

Please provide your email address to receive an email when new articles are posted on . Nearly half of men with metastatic castration-resistant prostate cancer eligible for PARP inhibitors do not get ...

Ovarian cancer has a poor prognosis, mainly because it is usually at an advanced stage by the time it is detected. Today 90% of people with breast cancer will be cured, whereas 50% of those with ...

PARP inhibitors, used to treat patients with cancer of the breast, ovaries, prostate and pancreas, work by inducing persistent DNA gaps in tumor cells with BRCA1 and BRCA2 mutations. The discovery ...

In mammals, 17 PARP family members have been discovered, and only 6 of these synthesize poly ADP-ribose (pADPr). PARP1, PARP2, and PARP3 have roles in DNA repair. PARP1 binds to DNA that has suffered ...