Immunome, Inc. had the European Medicines Agency validate the Marketing Authorization Application for varegacestat, an investigational, oral, once-daily gamma secretase inhibitor for the treatment of ...

New research has uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric ...

Based on structural similarities with other targets of the gamma-secretase system, researchers from Columbia University Irving Medical Center in the United States show that the SARS-CoV-2 receptor for ...

CAMBRIDGE, Mass., July 18, 2011 /PRNewswire/ --Satori™ Pharmaceuticals today announced the presentation of two posters at the Alzheimer’s Association International Conference on Alzheimer’s Disease ...

Acta Pharmaceuticals expects to begin a Phase I clinical trial in October 2026 for its lead asset, GSM-779690T.

Scientists at the Massachusetts General Hospital (MGH) have developed a molecular imaging probe to reveal Alzheimer's disease (AD)-related γ-secretase in rodents and macaques with translational ...

June 15, 2007 (Washington, DC) — A drug that deactivates gamma-secretase, an enzyme involved in amyloid-beta (Abeta) synthesis, appears to be safe and reduces plasma concentrations of Abeta in ...

A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's ...

AL102 is being assessed as part of the phase 3 RINGSIDE trial in patients with desmoid tumors. The FDA has given orphan drug designation to small molecule gamma secretase inhibitor (GSI) AL102 as a ...

The total amount of money invested in the project. The total cost includes EU contribution as well as other project costs not covered by EU funding. It is expressed in euros. Amount of money, by way ...