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Luteolin is a flavone-based polyphenol naturally found as glycosides, with a phenylpropanoid biosynthesis route. Luteolin, when ingested and absorbed in the intestine, converts from free to conjugated-form, thereby forming luteolin glucuronides, which are presumably responsible for a range of luteolin bioactivities.
This review mainly summarizes and understands the extraction process, detection methods, biological activities and product development patents of luteolin, in order to fully tap the research potential of luteolin and further develop high value-added products. The aim is to provide a scientific basis and theoretical basis for promoting the sustainable and healthy development of luteolin ...
Luteolin is a member of the flavone class of flavonoids and has become well-known for its extensive medical applications [15]. Because of the compound's well-known antioxidative, anti-inflammatory, and anti-cancer qualities, both doctors and researchers are interested in it.
Luteolin, a polyphenolic plant flavonoid, is recognized as one of the plausible bioactive components that can be notably intriguing for food applications and for fabricating active packaging systems with antimicrobial properties. Luteolin is a flavone-based polyphenol naturally found as glycosides, with a phenylpropanoid biosynthesis route.
Luteolin, luteolin-containing herbs, and Chinese herbal preparations containing luteolin may be used as important ingredients in the treatment of depression. However, further studies on the antidepressant mechanism of luteolin and development of its pharmacological preparations to improve its bioavailability are required to overcome these major ...
Luteolin, a natural flavone, present in significant amounts in various fruits and vegetables plays a key role as a chemopreventive agent in treating various types of cancer. By inducing apoptosis, initiating cell cycle arrest, and decreasing angiogenesis, metastasis, and cell proliferation, luteolin is used to treat cancer.
In Chinese traditional medicine, plants rich in luteolin have been utilized in the treatment of diseases such as hypertension, inflammatory disorders, and cancer. Luteolin exhibits multiple biological effects such as anti-inflammation, anti-allergy, and anticancer, and can function as either an antioxidant or a pro-oxidant biochemically.
Luteolin is a flavone, which widely exists in a variety of traditional Chinese medicine, fruits and vegetables. More and more evidence manifest that it has a variety of pharmacological activities such as anti-inflammatory, antioxidant, antibacterial, anti-tumor, neuroprotective and hepatoprotective activities [6], [7], [8], [9].
Conclusion luteolin effectively suppressed the inflammatory responses and M1 macrophage polarization through inhibiting EGFR/PI3K/AKT/NF-κB and EGFR/ERK/AP-1 signaling pathways in the treatment of acute P. aeruginosa pneumonia.
Abstract Luteolin (Lut) is a natural flavonoid compound endowed with medicinal properties but suffering from low water-solubility, stability, and bioavailability which limit its use in pharmaceutical applications. Encapsulation of luteolin in nanocarriers is providing a viable approach to overcome these drawbacks.
